PhD in Medical Immunology
immunology@orchidgen.com
I have completed my Ph.D. degree in Immunology under the mentorship of Prof. Behzad Baradaran, Department of Immunology, Tabriz University of Medical Sciences, Tabriz Iran.
My Ph.D. dissertation focused on understanding the effect of STAT3 inhibitor, STA-21 in combination with All-Trans Retinoic Acid (ATRA) on EAE mouse model of Multiple Sclerosis (MS). Moreover, during last 10 years, I have written several research and review papers on the role of cytokines and their signaling pathways in cancer and autoimmune diseases.
Studying medical Immunology for a Ph.D. degree and working for over 12 years in research and diagnostic laboratories has exposed me to laboratory skills that have improved my knowledge of expert laboratory techniques including developing mouse models of MS, Real-Time PCR, ELISA, western blotting, animal cell culture technologies, flow cytometry, H&E staining, LFB staining, and different computer skills and data analysis.
⦁ 1st rank out of 285 in the national Ph.D. entrance exam (2016)
⦁ Member of the National Organization for the Development of Exceptional Talents
1. Gharibi T, Barpour N, Hosseini A, Mohammadzadeh A, Marofi F, Ebrahimi-Kalan A, Nejati-Koshki K, Abdollahpour-Alitappeh M, Safaei S, Baghbani E, Baradaran B. STA-21, a
small molecule STAT3 inhibitor, ameliorates experimental autoimmune
encephalomyelitis by altering Th-17/Treg balance. International Immunopharmacology. 2023 Jun 1;119:110160.
2. Barpour N, Ghorbani M, Baradaran B, Jodari-Mohammadpour Z, Nejati-Koshki K, Abdollahpour-Alitappeh M, Dabbaghi R, Gharibi T. Development of an injectable
chitosan-based hydrogel containing Nano-hydroxy-apatite and Alendronate for MSC- based therapy. International Journal of Biological Macromolecules. 27 Jan 2024,
129737.
3. Gharibi T, Hosseini A, MaroH F, Oraei M, Jahandideh S, Abdollahpour-Alitappeh M, et
al. IL-21 and IL-21-producing T cells are involved in multiple sclerosis severity and
progression. Immunology letters. 2019;216:12-20.
4. Gharibi T, Babaloo Z, Hosseini A, Abdollahpour-Alitappeh M, Hashemi V, Marofi F, et al.
Targeting STAT3 in cancer and autoimmune diseases. European Journal of
Pharmacology. 2020:173107.
5. Gharibi T, Babaloo Z, Hosseini A, Marofi F, Ebrahimi?kalan A, Jahandideh S, et al. The
role of B cells in the immunopathogenesis of multiple sclerosis. Immunology. 2020.
6. Gharibi T, Ahmadi M, Seyfizadeh N, Jadidi-Niaragh F, Yousefi M. Immunomodulatory
characteristics of mesenchymal stem cells and their role in the treatment of multiple
sclerosis. Cellular immunology. 2015;293(2):113-21.
7. Gharibi T, Kazemi T, Aliparasti MR, Farhoudi M, Almasi S, Dehghanzadeh R.
Investigation of IL-21 gene polymorphisms (rs2221903, rs2055979) in cases with
multiple sclerosis of Azerbaijan, Northwest Iran. American journal of clinical and
experimental immunology. 2015;4(1):7.
8. Gharibi T, Majidi J, Kazemi T, Dehghanzadeh R, Motallebnezhad M, Babaloo Z. Biological effects of IL-21 on different immune cells and its role in autoimmune
diseases. Immunobiology. 2016;221(2):357-67.
9. Hosseini A, Gharibi T, Mohammadzadeh A, Ebrahimi-Kalan A, Jadidi-Niaragh F, Babaloo Z, Shanehbandi D, Baghbani E, Baradaran B. Ruxolitinib attenuates
experimental autoimmune encephalomyelitis (EAE) development as animal models of
multiple sclerosis (MS). Life Sciences. 2021 Jul 1;276:119395.
-DNA And RNA Extraction,CDNA Synthesis
-Flow Cytometry, Western Blot, ELISA
-Cell Culture Technology, Cell Proliferation Assay
-Animal Handling , Developing Mouse Model Of MS
-Isolation Of Mouse Organs Isolation Of Immune Cells
-Different Medical Laboratory Tests
-Luxol Fast Blue And H&E Staining
-CRISPR/Cas9 System And ChIP Assay Real-Time PCR
-Primer Designing